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Category: 14. Physical health, conventional medicine,
and folk medicine
WINF001. Winfield, John B., Philip L. Cohen,
Linda Bradley, et al. “IgM cryoprecipitation and anti-immunoglobulin
activity in dysgammaglobulinemia type I.” Clinical Immunology and
Immunopathology 23.1 (April 1982): 58-69. MEDLINE: 82234446.
ISSN: 0090-1229.
Publication type: Journal article
The authors studied serum from three siblings
in a large Lumbee family. The siblings had “dysgammaglobulinemia
Type I, characterized by increased serum IgM and IgD, absent or low serum
IgG and IgA, and increased numbers of IgM-containing plasmacytoid cells
in peripheral blood . . . [and] revealed several unusual serologic abnormalities
. . .” (abstract). The subjects were a 19-year-old male, a
24-year-old female, and a 35-year-old male. In each, the serum “exhibited
unusual single-component IgM cryoprecipitation” (p.58); each had
experienced pneumonia and otitis often since age 2.
The authors' major finding was “an unusual
IgM cryoglobulin in serum” (p.66) for each sibling. Only LgM was
“specifically concentrated in the cryoprecipitates” (p. 66).
Serum IgM was also well above normal rang in each subject. The authors
also note that “the probable basis for the elevated serum IgD levels
is increased IgD-secreting plasma cell activity in tonsils and adenoids”
(p. 68).
This annotation was last edited on June 13, 2002.
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